All customers using services at Center for Translational Genomics (CTG) should cite CTG by including the following sentence in the acknowledgments:

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Featured Publications

2023

• A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage. Uno K, Rastegar B, Jansson C, ..., Mengelbier LH, Gisselsson D. Mod. Pathol., 2023, 37 (1), 100382
   
• Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia. Garza R, Sharma Y, Atacho DAM, ..., Jakobsson J, Marklund N. Cell Rep, 2023, 113395
   
• LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification. Garza R, Atacho DAM, Adami A, ..., Douse CH, Jakobsson J.  Sci Adv, 2023, 9 (44), eadh9543
   
• UROSCAN and UROSCANSEQ: a large-scale multicenter effort towards translation of molecular bladder cancer subtypes into clinical practice – from biobank to RNA-sequencing in real time. Liedberg F, Abrahamsson J, Bernardo C, ..., Sjödahl G, Eriksson P. Scandinavian Journal of Urology, 2023, 57 (1-6), 2-9
   
• Clinical and genetic analyses of a Swedish patient series diagnosed with ataxia. Gorcenco S, Kafantari E, Wallenius J, ..., Karrman K, Puschmann A. J. Neurol., 2023
   
• Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs. Petruk G, Puthia M, Samsudin F, ..., Lindstedt S, Schmidtchen A. Nat Commun, 2023, 14 (1), 6097
   
• Single-cell multiomics of human fetal hematopoiesis define a developmental-specific population and a fetal signature. Sommarin MNE, Olofzon R, Palo S, ..., Karlsson G, Böiers C. Blood Adv, 2023, 7 (18), 5325-5340
   
• In vivo gene expression profile of Haemophilus influenzae during human pneumonia. Polland L, Rydén H, Su Y, Paulsson M. Microbiol Spectr, 2023, 11 (5), e0163923
   
• Trunk neural crest gene MOXD1 affects embryonic development. Fredlund E, Andersson S, Ferreira M, Mohlin S. pre-print 2023
   
• GATA2 mitotic bookmarking is required for definitive haematopoiesis. Silvério-Alves R, Kurochkin I, Rydström A, ..., Martin-Gonzalez J, Pereira CF. Nat Commun, 2023, 14 (1), 4645
   
• Restoring tumor immunogenicity with dendritic cell reprogramming. Zimmermannova O, Ferreira AG, Ascic E, ..., Svane IM, Pereira CF. Sci Immunol, 2023, 8 (85), eadd4817
   
• Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. Rastegar B, Andersson N, Petersson A, ..., Holmquist Mengelbier L, Gisselsson D. Clin. Cancer Res., 2023, 29 (14), 2668-2677
   
• Urodrill - a novel MRI-guided endoscopic biopsy technique to sample and molecularly classify muscle-invasive bladder cancer without fractionating the specimen during transurethral resection. Eriksson P, Berg J, Bernardo C, ..., Zackrisson S, Liedberg F. Eur Urol Open Sci, 2023, 53, 78-82
   
• Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. Konturek-Ciesla A, Dhapola P, Zhang Q, ..., Karlsson G, Bryder D. Cell Rep, 2023, 42 (4), 112304
   
• The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML. von Palffy S, Thorsson H, Peña-Martínez P, ..., Lilljebjörn H, Fioretos T. Blood Adv, 2023, 7 (7), 1204-1218
   
• Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia. Woodward EL, Yang M, Moura-Castro LH, ..., Foijer F, Paulsson K. Nat Commun, 2023, 14 (1), 1658
   
• Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing. Li H, Bräunig S, Dhapolar P, ..., Lang S, Scheding S. Elife, 2023, 12
   
• Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling. Shah K, Al Ashiri L, Nasimian A, Ahmed M, Kazi JU. Int J Mol Sci, 2023, 24 (5)
   
• Inactivation of RB1, CDKN2A, and TP53 have distinct effects on genomic stability at side-by-side comparison in karyotypically normal cells. Andersson N, Saba KH, Magnusson L, ..., Nord KH, Gisselsson D. Genes Chromosomes Cancer, 2023, 62 (2), 93-100
   
• Single-cell analysis of myeloid cells in HPV+ tonsillar cancer. Jimenez DG, Altunbulakli C, Swoboda S, ..., Greiff L, Lindstedt M. Front Immunol, 2023, 13, 1087843
   
• MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma. Fredlund E, Andersson S, Hilgert E, ..., van Nes J, Mohlin S. pre-print 2023
   
• The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney. Kha M, Krawczyk K, Choong OK, ..., Swärd K, Johansson ME. Am. J. Physiol. Renal Physiol., 2023, 324 (1), F75-F90

2022

• Developmental cues license megakaryocyte priming in murine hematopoietic stem cells. Kristiansen TA, Zhang Q, Vergani S, ..., Ungerbäck J, Yuan JBlood Adv 6 (24) 6228-6241
   
• Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis. A Grigoryan, D Zacharaki, A Balhuisen, C RM Côme, D Hidalgo Gil, A-K Frank, K Aaltonen, A Mañas, PE Bourgine et al. Science Translation Medicine 2022:14 (666). 
   
• Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance. Mañas A, Aaltonen K, Andersson N, Hansson K, Adamska A, Seger A, Yasui H, van den Bos H, Radke K, Esfandyari J, Bhave MS, Karlsson J, Spierings D, Foijer F, Gisselsson D, Bexell D. Sci Adv. 2022 Oct 28;8(43):eabq4617. 
   
• Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Evelyn Halitzki, Tasnim Zahan, Nejc Arh, Olga Zimmermannová Alexandra G. Ferreira, Hongzhe Li, Stefan Karlsson, Stefan Scheding, Carlos-Filipe Pereira. Science Immunology 2022;7(69). 
   
• Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction. Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerbäck, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Böiers, Ram Krishna Thakur, Göran Karlsson.
  Cell Reports 2022;39.
   
• Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study Jonas Öberg, Magnus Rasmussen, Pamela Buchwald, Bo Nilson, Malin Inghammar. Epidemiol Infect. 2022; 150: e8. 
   
• Bacteraemia and infective endocarditis with Streptococcus bovis-Streptococcus equinus-complex: a retrospective cohort study. Öberg J, Nilson B, Gilje P, Rasmussen M, Inghammar M.
  Infect Dis (Lond). 2022 Oct; 54(10):760-765. 
   
• A human-specific structural variation at the ZNF558 locus controls a gene regulatory network during forebrain development. Johansson PA, Brattås PL, Douse CH, Hsieh P, Adami A, Pontis J, Grassi D, Garza R, Sozzi E, Cataldo R, Jönsson ME, Atacho DAM, Pircs K, Eren F, Sharma Y, Johansson J, Fiorenzano A, Parmar M, Fex M, Trono D, Eichler EE, Jakobsson J. Cell Stem Cell 2022 29:52-69.
   
• Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia. Pilheden M, Ahlgren L, Hyrenius-Wittsten A, Gonzalez-Pena V, Sturesson H, Hansen Marquart HV, Lausen B, Castor A, Pronk CJ, Barbany G, Pokrovskaja Tamm K, Fogelstrand L, Lohi O, Norén-Nyström U, Asklin J, Chen Y, Song G, Walsh M, Ma J, Zhang J, Saal LH, Gawad C, Hagström-Andersson AK. Hemasphere 2022 Sep 30;6(10):e785

2021

• Distinct subcellular autophagy impairments in induced neurons from Huntington’s disease patients. Pircs K, Drouin-Oullet J, Horvath V, Gil J, Rezeli M, Garza R, Grassi DA, Sharma Y, St-Amour I, Harris K, Jönsson ME, Johansson PA, Vuono R, Fazal SV, Stoker T, Hersbach BA, Sharma K, Lagerwall J, Lagerström S, Storm P, Hebert SS, Marko-Varga G, Parmar M, Barker RA, Jakobsson J. Brain  2021 Dec 22:awab473 
   
• Activation of endogenous retroviruses during brain development causes an inflammatory response. Jönsson ME, Garza R, Sharma Y, Petri R, Södersten E, Johansson JG, Johansson PA, Atacho DA, Pircs K, Madsen S, Yudovich D, Ramakrishnan R, Holmberg J, Larsson J, Jern P, Jakobsson J. EMBO J. 2021 Mar 1
   
• Targeted genomic investigations in a population-based cohort of mantle cell lymphoma reveal novel clinically relevant targets. Rodrigues JM, Porwit A, Hassan M, Ek S, Jerkeman M.Leuk Lymphoma. 2021 Nov;62(11):2637-2647. doi: 10.1080/10428194.2021.1933480. Epub 2021 Jun 3.
   
• CD105 ⁺ CD90 ⁺ CD13 ⁺ identifies a clonogenic subset of adventitial lung fibroblasts. Kadefors M, Rolandsson Enes S, Åhrman E, Michaliková B, Löfdahl A, Dellgren G, Scheding S, Westergren-Thorsson G. Sci Rep 2021 Dec 24;11(1):24417.
   
• Amplification of ERBB2 (HER2) in embryonal rhabdomyosarcoma: A potential treatment target in rare cases? 
  Mitra S, Sydow S, Magnusson L, Piccinelli P, Törnudd L, Øra I, Ljungman G, Sandgren J, Gisselsson D, Mertens F. Genes Chromosomes Cancer 61 (1) 5-9 [2022-01-00; online 2021-09-01].
   
• Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation.. Engström K, Mandakh Y, Garmire L, Masoumi Z, Isaxon C, Malmqvist E, Erlandsson L, Hansson R S.Toxics 2021, 9(12), 338; https://doi.org/10.3390/toxics9120338
   
•  Different Responses to Neoadjuvant Chemotherapy in Urothelial Carcinoma Molecular Subtypes.
  Sjödahl G, Abrahamsson J, Holmsten K, Bernardo C, Chebil G, Eriksson P, Johansson I, Kollberg P, Lindh C, Lövgren K, Marzouka NA, Olsson H, Höglund M, Ullén A, Liedberg F. Eur. Urol. - (-) - [2021-11-12; online 2021-11-12]
   
• A comparison of rule-based and centroid single-sample multiclass predictors for transcriptomic classification.
  Eriksson P, Marzouka NA, Sjödahl G, Bernardo C, Liedberg F, Höglund M. Bioinformatics - (-) - [2021-11-12; online 2021-11-12]
   
• MAP3K6 mutations in late-onset neurovascular disease causing stroke, cognitive impairment and tremor. Ilinca A, Englund E, Samuelsson S, Truvé K, Kafantari E, Martinez-Majander N, Putaala J, Håkansson C, Lindgren A, Puschmann A.  Neurol Genet 2021;7:e548.
   
• cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology. Zhou J, Rasmussen M, Ekström P. Exp. Eye Res. 212 (-) 108752 [2021-11-00; online 2021-08-31]
   
• Transcriptomics paving the way for improved diagnostics and precision medicine of acute leukemia.
  Lilljebjörn H, Orsmark-Pietras C, Mitelman F, Hagström-Andersson A, Fioretos T.
  Semin. Cancer Biol. - (-) - [2021-10-01; online 2021-10-01]
   
• A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development.
  Johansson PA, Brattås PL, Douse CH, Hsieh P, Adami A, Pontis J, Grassi D, Garza R, Sozzi E, Cataldo R, Jönsson ME, Atacho DAM, Pircs K, Eren F, Sharma Y, Johansson J, Fiorenzano A, Parmar M, Fex M, Trono D, Eichler EE, Jakobsson J. Cell Stem Cell - (-) - [2021-10-01; online 2021-10-01]
   
• Genomic and transcriptomic characterization of desmoplastic small round cell tumors.
  Sydow S, Versleijen-Jonkers YMH, Hansson M, van Erp AEM, Hillebrandt-Roeffen MHS, van der Graaf WTA, Piccinelli P, Rissler P, Flucke UE, Mertens F. Genes Chromosomes Cancer 60 (9) 595-603 [2021-09-00; online 2021-05-17]
   
• Anti-tumor effects of rigosertib in high-risk neuroblastoma.
  Radke K, Hansson K, Sjölund J, Wolska M, Karlsson J, Esfandyari J, Pietras K, Aaltonen K, Gisselsson D, Bexell D. Transl Oncol 14 (8) 101149 [2021-08-00; online 2021-06-09]
   
• Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs.
  Pfisterer U, Bräunig J, Brattås P, Heidenblad M, Karlsson G, Fioretos T. Genes Chromosomes Cancer 60 (7) 504-524 [2021-07-00; online 2021-03-15]
   
• Human Primary Airway Basal Cells Display a Continuum of Molecular Phases from Health to Disease in Chronic Obstructive Pulmonary Disease. Wijk C S, Prabhala P, Michaliková B, Sommarin M, Doyle A, Lang S, Kanzenbach K, Tufvesson E, Lindstedt S, Leigh D N, Karlsson G, Bjermer L, Westergren-Thorsson G, Magnusson M. Am J Respir Cell Mol Biol 2021 Jul;65(1):103-113 doi: 10.1165/rcmb.2020-0464OC.
   
• Anti-tumor effects of rigosertib in high-risk neuroblastoma. Radke K, Hansson K, Sjölund J, Wolska M, Karlsson J, Esfandyari J, Pietras K, Aaltonen K, Gisselsson D, Bexell D. Transl Oncol. 2021 Aug;14(8):101149. doi: 10.1016/j.tranon.2021.101149. Epub 2021 Jun 9. PMID: 34118691
   
• Genomic and Phenotypic Evolution of Achromobacter xylosoxidans during Chronic Airway Infections of Patients with Cystic Fibrosis. Khademi SMH, Gabrielaite M, Paulsson M, Knulst M, Touriki E, Marvig RL, Påhlman LI mSystems - (-) e0052321 [2021-06-29; online 2021-06-29]
   
• Trailblazing precision medicine in Europe: A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany. Stenzinger A, Edsjö A, Ploeger C, Friedman M, Fröhling S, Wirta V, Seufferlein T, Botling J, Duyster J, Akhras M, Thimme R, Fioretos T, Bitzer M, Cavelier L, Schirmacher P, Malek N, Rosenquist R, GMS working groups and ZPM working groups. Semin. Cancer Biol. - (-) - [2021-05-24; online 2021-05-24]
   
• Precision diagnostics and therapy in hematological malignancies. Hellström Lindberg E, Cavelier L, Cammenga J, Andersson PO, Fioretos T, Rosenquist R. Läkartidningen 118 (-) - [2021-05-10; online 2021-05-10]
   
• Activation of endogenous retroviruses during brain development causes an inflammatory response.
  Jönsson ME, Garza R, Sharma Y, Petri R, Södersten E, Johansson JG, Johansson PA, Atacho DA, Pircs K, Madsen S, Yudovich D, Ramakrishnan R, Holmberg J, Larsson J, Jern P, Jakobsson 
  EMBO J. 40 (9) e106423 [2021-05-03; online 2021-03-01]
   
• High-Throughput and Automated Acoustic Trapping of Extracellular Vesicles to Identify microRNAs With Diagnostic Potential for Prostate Cancer. Ku A, Fredsøe J, Sørensen KD, Borre M, Evander M, Laurell T, Lilja H, Ceder Y. Front Oncol 11 (-) 631021 [2021-03-25; online 2021-03-25].
   
• Prevalence of germline pathogenic variants in 22 cancer susceptibility genes in Swedish pediatric cancer patients. von Stedingk K, Stjernfelt KJ, Kvist A, Wahlström C, Kristoffersson U, Stenmark-Askmalm M, Wiebe T, Hjorth L, Koster J, Olsson H, Øra I, Sci Rep 11 (1) 5307 [2021-03-05; online 2021-03-05]
   
• Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer. Kaminska K, Akrap N, Staaf J, Alves CL, Ehinger A, Ebbesson A, Hedenfalk I, Beumers L, Veerla S, Harbst K, Ehmsen S, Borgquist S, Borg Å, Pérez-Fidalgo A, Ditzel HJ, Bosch A, Honeth G. Breast Cancer Res. 23 (1) 26 [2021-02-18; online 2021-02-18]
   
• multiclassPairs: An R package to train multiclass pairbased classifier. Marzouka NA, Eriksson P
  Bioinformatics - (-) - [2021-02-05; online 2021-02-05]
   
•  Isolation of high-yield and -quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts. Stegmayr J, Alsafadi HN, Langwiński W, Niroomand A, Lindstedt S, Leigh ND, Wagner DE. Am J Physiol Lung Cell Mol Physiol 320 (2) L232-L240 [2021-02-01; online 2020-10-28]
   
• Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells.
  Niklasson CU, Fredlund E, Monni E, Lindvall JM, Kokaia Z, Hammarlund EU, Bronner ME, Mohlin S
  Dev. Dyn. 250 (2) 191-236 [2021-02-00; online 2020-09-26]
   
• BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features.
  Tolomeo D, Agostini A, Macchia G, L'Abbate A, Severgnini M, Cifola I, Frassanito MA, Racanelli V, Solimando AG, Haglund F, Mertens F, Storlazzi CT. Hum Cell 34 (1) 238-245 [2021-01-00; online 2020-08-27]

2020

•  Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.
  Xu Y, Jurkovic-Mlakar S, Lindh CH, Scott K, Fletcher T, Jakobsson K, Engström K.
  Environ Int 145 (-) 106148 [2020-12-00; online 2020-09-30].
   
• Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship.
  Marzouka NA, Lindgren D, Eriksson P, Sjödahl G, Bernardo C, Liedberg F, Axelson H, Höglund M.
  Sci Rep 10 (1) 19539 [2020-11-11; online 2020-11-11]
   
•  Inducible Deletion of YAP and TAZ in Adult Mouse Smooth Muscle Causes Rapid and Lethal Colonic Pseudo-Obstruction. Daoud F, Holmberg J, Alajbegovic A, Grossi M, Rippe C, Swärd K, Albinsson S. Cellular and Molecular Gastroenterology and Hepatology 11 (2) 623-637 [2020-09-28; online 2020-09-28].
   
• Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma. Hansson K, Radke K, Aaltonen K, Saarela J, Mañas A, Sjölund J, Smith EM, Pietras K, Påhlman S, Wennerberg K, Gisselsson D, Bexell D. Sci Transl Med 12 (562) - [2020-09-23; online 2020-09-25].
   
• Multiplex profiling of serum proteins in solution using barcoded antibody fragments and next generation sequencing Brofelth M, Isinger Ekstrand A, Gour S, Jansson R, Hedhammar M, Elleby B, Kvist A, Wingren C, Axelsson U, Borrebaeck C. Communications Biology volume 3, Article number: 339 (2020) Open Access Published: 03 July 2020.
   
• A dynamic mutational landscape associated with an inter‐regionally diverse immune response in malignant rhabdoid tumour. Yasui H., Valind A., Karlsson J., Pietras C., Jansson C., Wille J., Romerius P., Backman T., Gisselsson D. J Pathol 2020; 00: 000–000 Published online 22 July 2020 in Wiley Online Library First published: 16 June 2020 https://doi.org/10.1002/path.5490
   
• 13q12.2 Deletions in Acute Lymphoblastic Leukemia Lead to Upregulation of FLT3 Through Enhancer Hijacking 
  M. Yang, S. Safavi, E. L. Woodward, N. Duployez, L. Olsson-Arvidsson, J. Ungerbäck, M. Sigvardsson, M. Zaliova, J. Zuna, T. Fioretos, B. Johansson, K. H. Nord, K. Paulsson. Blood. 2020 May 8;blood.2019004684.
   
• PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells. Hofvander J, Jo VY, Fletcher CDM, Puls F, Flucke U, Nilsson J, Magnusson L, Mertens F. Mod. Pathol. 33 (7) 1331-1340 [2020-07-00; online 2020-01-13]
   
•  Molecular changes during progression from nonmuscle invasive to advanced urothelial carcinoma.
  Sjödahl G, Eriksson P, Patschan O, Marzouka NA, Jakobsson L, Bernardo C, Lövgren K, Chebil G, Zwarthoff E, Liedberg F, Höglund M. Int. J. Cancer 146 (9) 2636-2647 [2020-05-01; online 2019-11-14]
   
• Recurrent fusions between YAP1 and KMT2A in morphologically distinct neoplasms within the spectrum of low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma. 
  Puls F, Aigamy A, Flucke U, Menzel T, Sumathi VP, Ploegmakers M, Stoehr R, Kindblom L-G, Hansson M, Sydow S, Arbajian E, Mertens F (2020). Am J Surg Pathol 44:594-606.
   
• Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells. Li H, Lim HC, Zacharaki D, Xian X, Kenswil KJG, Bräunig S, Raaijmakers MHGP, Woods NB, Hansson J, Scheding S. Haematologica 105 (5) 1206-1215 [2020-05-00; online 2019-08-01]
   
• Deep sequencing of myxoinflammatory fibroblastic sarcoma. Arbajian E, Hofvander J, Magnusson L, Mertens F. Genes Chromosomes Cancer 59 (5) 309-317 [2020-05-00; online 2020-01-31]
   
• Genomic and transcriptomic features of dermatofibrosarcoma protuberans: unusual chromosomal origin of the COL1A1-PDGFB fusion gene. Köster J, Arbajian E, Viklund B, Isaksson A, Hofvander J, Haglund F, Bauer H, Magnusson L, Mandahl N, Mertens F. Cancer Genet 2020 241:34-41.
   
• Clonal competition within complex evolutionary hierarchies shapes AML over time. Sandén C, Lilljebjörn H, Orsmark Pietras C, Henningsson R, Saba KH, Landberg N, Thorsson H, von Palffy S, Peña-Martinez P, Högberg C, Rissler M, Gisselsson D, Lazarevic V, Juliusson G, Ågerstam H, Fioretos T.
  Nat Commun. 2020 Feb 5;11(1):579

2019

• Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia  Yang M, Vesterlund M, Siavelis I, ..., Lehtiö J, Paulsson K 
  Nat Commun 10 (1) - [2019-12-00; online 2019-04-03]
   
• Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile 
  Hofvander J, Puls F, Pillay N, ..., Nilsson J, Mertens F. J. Pathol 249 (4) 425-434 [2019-12-00; online 2019-08-27]
   
• FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis 
  Hyrenius-Wittsten A, Pilheden M, Falqués-Costa A, ..., Järås M, Hagström-Andersson AK. Leukemia 33 (9) 2310-2314 [2019-09-00; online 2019-04-05]
   
• Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells. Li H, Lim HC, Zacharaki D, ..., Hansson J, Scheding S 
  Haematologica - (-) haematol.2019.216648 [2019-08-01; online 2019-08-01]
   
• Gene fusion involving the insulin‐like growth factor 1 receptor in an ALK ‐negative inflammatory myofibroblastic tumours. Piarulli G, Puls F, Wängberg B, ..., Arbajian E, Mertens F. Histopathology 74 (7) 1098-1102 [2019-06-00; online 2019-04-24]
   
• A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing . Ku A, Ravi N, Yang M, ..., Lilja H, Ceder Y 
  PLoS ONE 14 (5) e0217507 [2019-05-29; online 2019-05-29]

2018

• Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Li JF, Dai YT, Lilljebjörn H, ..., Chen SJ, Huang JY. Proc. Natl. Acad. Sci. U.S.A. 115 (50) E11711-E11720 [2018-12-11; online 2018-11-28]
   
• Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers. 
  Valind A, Wessman S, Pal N, ..., Sandstedt B, Gisselsson D . Pediatr Blood Cancer 65 (11) e27301 [2018-11-00; online 2018-07-03]
   
• Neuroblastoma with flat genomic profile: a question of representativity? 
  Valind A, Öra I, Mertens F, Gisselsson D. BMJ Case Reports - (-) bcr-2018-225568 [2018-09-08; online 2018-09-08]
   
• Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury.  Kapur R, Kim M, Rebetz J, ..., Speck ER, Semple JW. Blood Adv 2 (13) 1651-1663 [2018-07-10; online 2018-07-12]
   
• Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling. . Roswall P, Bocci M, Bartoschek M, ..., Eriksson U, Pietras K. Nat. Med. 24 (4) 463-473 [2018-05-00; online 2018-03-12]
   
• Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative Brueffer C, Vallon-Christersson J, Grabau D, ..., Borg Å, Saal LH. JCO Precision Oncology - (2) 1-18 [2018-03-00; online 2018-03-00]
   
• Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative.  Rydén L, Loman N, Larsson C, ..., Saal LH, Borg Å 
  Br J Surg 105 (2) e158-e168 [2018-01-00; online 2018-01-18]

2017

• Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow.  Lazarevic V, Orsmark-Pietras C, Lilljebjörn H, ..., Juliusson G, Fioretos T. 
  Blood - (-) - [2017-11-30; online 2017-11-30]
   
• New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia. 
  Lilljebjörn H, Fioretos T . Blood 130 (12) 1395-1401 [2017-09-21; online 2017-08-04]
   
• Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification . Karlsson A, Brunnström H, Micke P, ..., Planck M, Staaf J 
  Journal of Thoracic Oncology 12 (8) 1257-1267 [2017-08-00; online 2017-08-00]
   
• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. 
  Davies H, Glodzik D, Morganella S, ..., Stratton MR, Nik-Zainal S . Nat. Med. 23 (4) 517-525 [2017-04-00; online 2017-03-13]
   
• Identification of two distinct mesenchymal stromal cell populations in human malignant glioma. 
  Svensson A, Ramos-Moreno T, Eberstål S, Scheding S, Bengzon J . J. Neurooncol. 131 (2) 245-254 [2017-01-00; online 2016-10-18] 
   
• Identification of two distinct mesenchymal stromal cell populations in human malignant glioma 
  Svensson A, Ramos-Moreno T, Eberstål S, Scheding S, Bengzon J . J Neurooncol 131 (2) 245-254 [2017-01-00; online 2016-10-18]